Taking methotrexate is not recommended for the New Crown vaccine, and you need to stop taking the medication and get your doctor’s approval before getting vaccinated. 1. Methotrexate is an immunosuppressant, which can affect the patient’s immune function, while the New Crown vaccine, after entering the human body, mainly acts on the immune system. Therefore, it is not recommended that people who are taking methotrexate orally should receive the New Crown vaccine to avoid adverse reactions. 2. If the patient is using immunosuppressive drugs, it means that the disease has not fully recovered, so the safety of vaccination is unknown. It is recommended that the patient consult his/her primary care physician after the disease has been fully controlled to clarify the current progress of the disease and his/her physical status, and then proceed with the vaccination with the consent of the physician.