Elderly patients should pay attention to various things when applying various medications for pain. First of all, it is necessary to make a classification of analgesic drugs. Initially, they can be divided into non-steroidal drugs, and the representative drugs are fenbuterol, fotarolim and so on. The next is steroidal drugs such as glucocorticoids. The representative drugs are methylprednisolone tablets. Next are opioids or weak opioids. The representative drugs are tramadol and oxycodone tablets. The following are introduced as follows: 1. For non-steroidal drugs These drugs play a key role in chronic pain. But their analgesia at the same time inevitably brings some side effects, such as the occurrence of cardiovascular and cerebrovascular adverse events, coagulation dysfunction, liver and kidney function damage. These drugs are not easily used in the long term. Carefully distinguish the drugs in this category can be divided into two categories, the first is non-selective non-steroidal drugs. Most of the drugs are such drugs. The second category is highly selective non-steroidal drugs. The second group of drugs is less common and mainly includes celecoxib, etoricoxib, and parecoxib sodium (for intravenous drip). In general, the difference between the two classes of drugs lies in the damage to the mucosa of the gastrointestinal tract, with the former showing more gastrointestinal problems with long-term application. The second class of drugs has very few gastrointestinal reactions. Long-term application of both types of drugs can lead to the incidence of cardiovascular and cerebrovascular adverse events. The liver and kidney functions as well as coagulation should be monitored regularly when taking these drugs. Particular attention should be paid to the two NSAIDs, which should not be used together in either category. This is the application of analgesic effect does not increase, while the side effects are superimposed. 2, for steroidal drugs Long-term application of glucocorticoids can lead to hypertension, hyperkalemia, hyperglycemia, centripetal obesity, osteoporotic fractures, etc.. In addition it can induce gastrointestinal ulcers and bleeding. Some elderly patients with rheumatoid arthritis suffer from long-term application of steroids, thus leading to the above-mentioned adverse effects. For this kind of patients, if combined with the use of non-steroidal drugs, it is very easy to lead to chronic gastritis and gastrointestinal ulcers. 3, for weak opioids or opioid drugs. For older patients with a more severe degree, it is advisable to start with a small dose when applying weak opioids for treatment. This should be for the relatively poor liver and kidney function of the elderly, the ability to metabolize and excrete drugs is reduced, and the blood concentration of drugs is relatively high. The blood concentration of the drug is relatively high, and the drug can easily accumulate and become toxic in the body. Once the drug reaction is heavy, it can lead to serious nausea, vomiting, constipation, dizziness, drowsiness, and even respiratory depression. Therefore, it is more appropriate to use drugs with a smaller half-life. For example, when using tramadol, you can start with half a tablet. After adaptation, it can be gradually increased to 1 tablet. For patients with poor liver and kidney function, the dosage should be reduced as appropriate. If the analgesic effect is not good, the dosage can be increased but the corresponding drugs must be applied to counteract the adverse effects. In conclusion, analgesic drugs are a double-edged sword, and we must pay attention to the adverse drug reactions while analgesic. To achieve reasonable analgesia, only to avoid or counteract the adverse reactions can better serve elderly patients.