About 40% of myocardial infarction and 29% of sudden cardiac death occur in the early morning and morning, and the incidence of stroke is 3 to 4 times higher than other times of the day. The prevention measure with curative significance is to strengthen the antihypertensive treatment. Normally, human blood pressure does not fluctuate like a smooth straight line during 24 hours a day. Although not as alarming as the stock market fluctuations in the past two years, but also has a “two peaks and a valley” phenomenon. The two peaks occur in the early morning 6:00-10:00 and 4:00-6:00 pm, and the former is higher than the latter. The “valley” occurs between 2:00 a.m. and 4:00 a.m. The overall trend is to increase during the day and decrease during the night (blood pressure at night is 10% to 20% lower than the daytime peak), and we call this trend a “spoon curve”. Early morning, the time of death This low blood pressure during nighttime sleep and the significant increase in blood pressure in the early morning hours is called the “morning peak phenomenon”, which may be related to the body’s biological rhythm. For a long time, in order to adapt to the natural alternation of day and night, humans have developed the habit of working at sunrise and resting at sunset. Therefore, the function regulation of the human body systems also comply with this cyclical pattern change. Therefore, at dawn, the autonomic nerves and related humoral factors (such as adrenaline, etc.) that dominate the cardiovascular system enter a state of excitement and stress, prompting the heart rate to accelerate, blood pressure to rise, the heart’s blood displacement to increase, and blood viscosity and coagulation to meet the needs of daily work and brain activity. But for hypertensive patients, this volatility will be greater, early in the morning when you wake up blood pressure may be beyond the normal range. According to the survey, about 40% of myocardial infarction and 29% of sudden cardiac death occur at this time, the incidence of stroke at this time is 3 to 4 times that of other times, it can be said to be the time of death like to visit. The “morning peak phenomenon” of blood pressure coincides with the high incidence of major cardiovascular events, suggesting a close correlation between the two. Therefore, experts specifically caution that controlling the “morning peak phenomenon” is critical to preventing cardiovascular events and preventing diseases such as hypertension, coronary artery disease and cerebral atherosclerosis from being aggressive at dawn. Strengthen antihypertension to keep death at the door So, how can we reduce the occurrence of cardiovascular and cerebrovascular malignant events during the “morning peak” and keep death at the door? After getting up, sit in bed for a while before getting out of bed; take your medicine within 5 minutes of getting up, and taking medicine on an empty stomach will not affect its effectiveness or cause harm to your stomach. These are some small details of life, while strengthening antihypertensive treatment is a preventive measure with curative significance. In addition to the always emphasized medication in accordance with the doctor’s advice, to control blood pressure below 140/90 mm Hg (coronary heart disease, diabetic patients require to drop to 130/80 mm Hg or less), improve lifestyle, such as weight loss, quit smoking, limit alcohol, limit salt, adhere to physical exercise, should also pay attention to the following points. 1, try to use stronger and longer duration and smooth antihypertensive drugs, such as temisartan, amlodipine, etc., given once a day early in the morning after waking up, not only can control the average level of blood pressure throughout the 24 hours, but also can effectively stop the rise of blood pressure 18 to 24 hours (the last 6 hours) after taking the drug, which is the best treatment method. 2, for the night and early morning blood pressure is difficult to control, can be in the afternoon or before bedtime to take another drug (such as after waking up after taking the first drug, in the evening around 6: 00 again); and the combination of drugs, can be separated into two doses, so that the drug on the blood pressure of the time control range more widely. 3, if there are conditions, you can use the drug time release preparation (COER, control extend release), this preparation using the absorption of the rapid onset of short-acting drugs, after taking before bedtime drug release in the morning, control immediate blood pressure, but the variety of such preparations are few, and expensive. 4. Take blood pressure measurements regularly (within 5 minutes after waking up in the morning and before taking the medication), and if you find any danger signs, you should seek medical advice and adjust the medication in time.