Problems like cranial defects have become more and more common in our life, and many people suffer from cranial defects due to some trauma, traffic accidents or diseases. Cranial defects can cause a lot of uncomfortable symptoms, such as dizziness and nausea, which seriously affects the patient’s life and health, so once the problem of cranial defects occurs, it is necessary to save the health by doing cranial bone repair surgery. The selection of materials for cranial bone repair has always been a big problem. The selection of materials for cranial bone repair is actually very demanding, and if the materials are not suitable for one’s own physiological environment, then all kinds of serious problems may occur, causing a lot of discomfort, and may even be life-threatening. So, can autologous bone be used for cranial bone repair? This is similar to organ transplantation, except that the transplanted material is not a living organ, but the corresponding repair material. The biggest fear in organ transplantation is tissue incompatibility and rejection, which is also a problem in cranial bone repair. In many clinical cases, the poor tissue compatibility of the material will lead to postoperative rejection reaction, and even finally the scalp is destroyed and the material is exposed. Then some patients ask whether cranial bone repair can use autologous bone, and whether using autologous bone can solve the problem of rejection! In fact, in the history of the development of cranial bone repair, it is true that there have been precedents of using autogenous bone repair, such as using tibia, rib, shoulder swelling bone, skeleton bone and sternum bone as cranial bone substitutes, but there are also many problems. First of all, there are limited materials to be taken, the human body bones are so many, each in its own way, repairing the cranium may cause another defect; in addition to the need to open up a second surgical area, which is more traumatic and risky; in many cases, the autogenous bone transplantation may be absorbed, and the shape of the autogenous bone structure is fixed, it is difficult to mold, and other problems. Therefore, autologous bone repair has long been eliminated. At present, the most ideal cranial bone repair material should be polyether ether ketone PEEK material, the material has quite good tissue compatibility, there will be no rejection reaction. In addition, the properties of PEEK material are very close to those of autologous skull, and it has gradually become the latest trend of cranial bone repair materials.