Hypertrophy and injury of infrapatellar fat pad degeneration without obvious symptoms can be appropriate rest, when the symptoms are obvious can be treated with drugs, long course of the disease, the symptoms do not relieve the person can be surgical resection. 1. General treatment: hypertrophy and injury of infrapatellar fat pad can have no obvious symptoms in the early stage, so appropriate rest can reduce the stimulation to the hypertrophic injury of the fat pad to avoid aggravation of the condition. 2. Medication: For hypertrophy and degeneration of infrapatellar fat pad secondary to knee trauma, knee degeneration, etc., in most cases, it is a local aseptic inflammatory reaction, thus pain, soreness and other discomforts, so non-steroidal anti-inflammatory drugs such as bisacodyl, acetaminophen, etc. can be taken orally to alleviate the pain. 3. Surgery: For some long duration of the disease, symptoms are not relieved after drug treatment, surgery can be considered to remove the lesion of the fat pad. Hypertrophy of infrapatellar fat pad refers to the occurrence of congestion and edema after injury, as well as the occurrence of aseptic inflammation and even adhesion with the surrounding tissues at a later stage, therefore, hypertrophy of infrapatellar fat pad should be standardized treatment to avoid affecting the prognosis. Drug treatment is recommended under the guidance of a doctor.