The need for medication in hepatitis B virus carriers is determined by the patient’s serum HBV DNA level, liver function, and severity of liver disease. Hepatitis B virus carriers appear to need oral antiviral drugs for treatment more often. 1. Patients with positive serum HBV DNA, if the alanine aminotransferase (ALT) is persistently greater than one times the normal value, and exclude other causes of ALT elevation. 2. Cirrhosis. 3. Serum HBV DNA is positive and ALT is normal. With one of the following situations. (1) The presence of significant liver inflammation or liver fibrosis on liver histology. (2) Regular review of ALT every three months, normal for one year, family history of cirrhosis or hepatocellular carcinoma and age older than 30 years. (3) Regularly review ALT every three months, normal for 1 year, no family history of cirrhosis or hepatocellular carcinoma and age greater than 30 years, with significant hepatic inflammation or hepatic fibrosis on liver histology. (4) Regular rechecking of ALT every three months, normal for 1 year, and those with extrahepatic manifestations associated with hepatitis B virus (glomerulonephritis, vasculitis, polyarteritis nodosa. Peripheral neuropathy, etc.). If hepatitis B virus carriers are diagnosed, they need to go to the hospital regularly to review liver function and other indicators, and whether they need to take medication should be in accordance with the doctor’s instructions.