Sulodexide has been found to be effective in diabetic nephropathy and other diseases in clinical studies. Sulodexide is a glucosaminoglycan with strong antithrombotic effect, which is suitable for vascular diseases where there is a risk of thrombosis. Clinical studies have found that this drug is effective in early diabetic nephropathy, which can significantly reduce urinary proteins and vascular endothelial cell damage, increase plasma albumin, and improve the state of micro-inflammatory response in such patients. However, Sulodexide may cause gastrointestinal disorders such as nausea and vomiting, epigastric discomfort and pain, and is contraindicated for those who are allergic to the product, heparin or heparin-like medicines, as well as patients with bleeding tendencies. It is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects. Patients with kidney disease are advised to go to regular hospitals in time and standardize the treatment under the guidance of doctors, do not self-medicate.