The general price of HFMD vaccine is 160~300 dollars, the specific price is related to the region and vaccine manufacturers and other factors. HFMD vaccine belongs to Class II vaccine, which is mainly used to prevent HFMD caused by EV71, and needs to be vaccinated at your own expense. In general, the price of HFMD vaccine is 160~300 RMB, and a total of two injections are required. However, due to the variability of regions and vaccine manufacturers, it is not possible to generalize the exact cost, and the actual local charges should prevail. The HFMD vaccine is intended for susceptible children over 6 months of age and under 5 years of age, but it is not recommended for those who are in the period of fever, acute illness, or allergic to vaccine components. In addition, some of the vaccinated people will have symptoms such as itching and swelling locally after vaccination, as well as systemic adverse reactions such as fever, diarrhea, and loss of appetite. It is recommended to understand the relevant issues before receiving HFMD vaccination to avoid adverse effects.