Knee straightening will stutter, mainly with joint degenerative disease, inflammation or trauma, etc., need to clarify the cause of the disease to give nutritional joints or non-steroidal anti-inflammatory drugs, blood circulation and blood stasis of the drug treatment, do not blindly use drugs. 1. Degenerative joint lesions: degenerative joint lesions in the knee joint can easily lead to internal structural disorders of the knee, resulting in the symptom of thumping when the knee is straightened, which can be treated with medicines that nourish the joint cartilage, such as chondroitin sulphate, glucosamine, and so on. 2. Inflammation: If there is inflammation in the knee joint, such as osteoarthritis, it is easy to have the symptom of thumping when the knee is straightened out, and you can take non-steroidal anti-inflammatory drugs, such as meloxicam, naproxen, and so on. 3. Trauma: If the knee is impacted by external forces leading to localized injuries, it is usually easy to cause functional problems in the knee, which will lead to the symptoms of thumping when the knee is straightened. In terms of medication, you can choose to take drugs to activate blood circulation and remove blood stasis, such as Panax ginseng powder. The above medication should be taken in accordance with the doctor’s prescription. It should also be noted that if the internal structure of the knee has changed, medication alone may not be able to cure it completely. We can consider sports rehabilitation or knee arthroscopy to restore the function of the knee joint as much as possible and to prevent the sequelae of motor dysfunction in the later stage.