Normal alpha-fetoprotein with nodules requires further investigation to clarify the nature of the liver nodules. Although alpha-fetoprotein is a specific tumor marker for liver cancer, not all liver cancers cause elevated alpha-fetoprotein, and about 30% of liver cancers do not have elevated alpha-fetoprotein. When there are suspicious liver nodules, further examination, such as liver enhancement CT or liver magnetic resonance examination, is needed to further exclude the possibility of liver cancer, and for those who cannot exclude liver malignancy, percutaneous liver aspiration biopsy is needed to clarify the pathological diagnosis and to confirm whether the liver nodules are benign or malignant. If the nodule is a benign lesion, it can be observed or operated. If the nodule is hepatocellular carcinoma, surgery is recommended for early clinical stage, and targeted, interventional, radiofrequency and other comprehensive treatments are recommended for the middle and late clinical stages. If the alpha-fetoprotein is normal, but there are nodules, it is recommended to go to the hospital in time to get a clear diagnosis and treatment, so as not to delay the condition.