Aminotransferase is an indicator that reflects the degree of hepatocyte inflammation and necrosis, the normal value of aminotransferase is usually between 0~40U/L, hepatitis B aminotransferase 500U/L is usually more serious, representing obvious hepatocyte damage. Hepatitis B aminotransferase, including alanine aminotransferase and glutamic oxalate aminotransferase, is an important indicator of liver function. If hepatitis B aminotransferase 500U/L is more than 500U/L, it usually indicates that there is obvious hepatocellular damage, which means that it is more serious, and it needs to be treated in time in order to avoid the emergence of acute and chronic hepatic failure and other undesirable conditions. Hepatitis B aminotransferase may be elevated due to the effects of drugs, alcohol consumption, cholecystitis, cholangitis, viral hepatitis and other factors, need to consult a doctor in a timely manner, to clarify the cause of the disease and then targeted treatment.