Patients with hypothyroidism require standardized levothyroxine (L-T4) replacement therapy under the supervision of a medical professional. Hypothyroidism is a generalized hypometabolic syndrome caused by various reasons. Typical hypothyroid patients may have chills, fatigue, swelling sensation of hands and feet, drowsiness, memory loss, less sweating, joint pains, weight gain, constipation, menstrual disorders in women, or excessive menstruation, infertility and so on. The goal of levothyroxine therapy for patients with hypothyroidism is to restore serum thyroid stimulating hormone and thyroid hormone levels to within the normal range, and may require lifelong medication. Patients with hypothyroidism are advised to seek prompt medical attention, follow the doctor’s instructions for standardized treatment, and pay attention to monitoring changes in thyroid function.