High free fatty acids may be due to diabetes, acromegaly, Cushing’s syndrome and other conditions, patients need to follow the doctor’s instructions for drug treatment, surgical treatment, general measures and so on. 1. Diabetes mellitus: Usually, patients need to be treated with glucose-lowering drugs such as gliclazide, glipizide, repaglinide, metformin, acarbose and so on as prescribed by the doctor. Some patients can also be injected with insulin or GLP-1 agonists. Patients usually need to develop good dietary habits, ensure regular work and rest and appropriate physical exercise, which is conducive to blood glucose control, and if necessary, patients can also under the guidance of the doctor for surgical treatment. 2. Acromegaly: Usually the patients who can not be operated, can follow the doctor’s instructions to use octreotide, pareptide and other growth inhibitor analogues treatment, some patients can also be used with the use of pegylated somatostatin and other GH receptor antagonist treatment. For other patients, minimally invasive transnasal sinus surgery and traditional craniotomy should be performed under the guidance of doctors. If necessary, patients can also be matched with radiotherapy. 3. Cushing’s syndrome: Usually, patients can follow the doctor’s instructions to use drugs affecting neurotransmitters such as ergometrine, bromocriptine, etc., and some patients can also be used with ketoconazole, dichlorodiphenyl dichloroethylene and other adrenocorticotropic hormone synthesis inhibitors. If the patient’s condition is more serious, surgery to remove the lesion is also required under the guidance of the doctor. In addition to the above factors, high free fatty acids can also be caused by hyperthyroidism, myocardial infarction and other conditions. It is recommended that patients with high free fatty acids should promptly identify the cause of the disease and follow the doctor’s instructions for reasonable treatment.