There are more reasons for constipation to be ineffective after the use of corkscrew, such as drug tolerance, organic lesions, etc. Intervention can be made according to the cause of the disease through enemas, medication, and surgical treatments. 1. Drug tolerance: Keserol is a stimulant drug, long-term use will make the rectal wall produce tolerance, resulting in the ineffectiveness of Keserol, you can go to the hospital for enema treatment to alleviate the symptoms, or follow the doctor’s instructions for oral lactulose, polyethylene glycol, moxapride and other drugs. 2. Organic lesions: such as intestinal cancer, proctitis, etc., can cause constipation caused by narrowing and obstruction of the rectal intestinal canal, which is ineffective after the use of Keflex. It is recommended that after clear diagnosis and condition assessment by professional doctors, surgical resection is the treatment of choice, and at the same time can be combined with radiotherapy and chemotherapy. In addition, hypothyroidism, diabetes, etc. can also cause constipation patients appeared after the use of Kefir is ineffective, it is recommended to consult a doctor in a timely manner, under the guidance of a professional physician to identify the causes of the disease, and then follow the doctor’s instructions for the causes of standardized treatment.