There may be in-stent thrombosis after random discontinuation of medication after stent placement, and consequently cardiovascular events may increase and potentially fatal complications may occur. After the stent is put in the general need for dual antiplatelet therapy, usually oral aspirin, clopidogrel and other anticoagulant drugs, can prevent thrombosis within the stent; according to the stent placement site, as well as the lesion, the routine recommendations aspirin can be long-term use, clopidogrel can be discontinued after taking more than one year of review of the stabilization of the condition, in the absence of clear contraindications, it is best not to stop anticoagulant drugs. At the same time in the process of taking anticoagulant drugs, need to pay attention to the risk of bleeding, common gastric bleeding may be, once a serious bleeding adverse reaction, according to the doctor’s advice to stop the drug for a short time, bleeding control can continue to take the drug or change the drug to continue anticoagulation. Therefore, it is necessary to consult a professional doctor about the taking and stopping of anticoagulants after stenting, and not to stop the drugs by oneself in order to avoid causing adverse reactions.