Children with Kawasaki disease who remain febrile after treatment with gammaglobulin input can be intervened with the use of medications such as aspirin and prednisone. After a clear diagnosis of Kawasaki disease, early initiation of standardized treatment is recommended. Its treatment is mainly based on high-dose gammaglobulin infusion, which can rapidly enhance the body’s anti-infective ability and immunomodulatory function. After the use of gammaglobulin in children with Kawasaki disease, some of the patients will have high fever again, which is actually a normal situation. Usually, on the basis of gammaglobulin infusion, aspirin is added, which can be used to antagonize platelet aggregation and avoid thrombosis on the one hand, and has certain anti-inflammatory and antipyretic effects on the other. However, it should be noted that in the acute stage of Kawasaki disease, if there is severe liver function abnormality, the use of aspirin is not recommended, and glucocorticoid therapy such as dexamethasone can be used instead. If the disease cannot be effectively controlled on the basis of the above medication, shock therapy with glucocorticoids such as prednisone acetate can be used as appropriate. The above drugs such as gammaglobulin need to be used under the guidance of clinicians; for the suspicion or appearance of Kawasaki disease, it is recommended to go to the hospital in time for early and regular treatment.