Lobar pneumonia is usually Streptococcus pneumoniae infection, when it is combined with mycoplasma infection, it can be treated by general treatment, drug treatment and so on. 1. General treatment: patients are instructed to take bed rest and avoid staying up all night. Diet, supplement protein and vitamins, strengthen nutritional support. 2. Drug treatment (1) Lobar pneumonia: clinically commonly used antibacterial drugs preferred penicillin, to which allergic patients can choose ceftriaxone, fluoroquinolones such as levofloxacin, moxifloxacin and other drugs to replace. (2) Mycoplasma pneumonia: macrolides are often used in the clinic, such as erythromycin, erythromycin and azithromycin. Patients who are not sensitive to macrolides can take fluoroquinolones such as levofloxacin and moxifloxacin. Patients should go to the hospital as soon as possible to improve the relevant examination such as chest CT, blood routine, etc. to assess the condition. The above mentioned drugs should be taken under the guidance of professional doctors.