In recent years, the impact of mycoplasma on infertility has been a growing concern, and it is increasingly important to correctly recognize the impact of mycoplasma on human conception and diagnosis and treatment. Mycoplasma is a kind of microorganism, the size is between bacteria and viruses, the biggest characteristic is that there is no cell wall, it is difficult to see clearly under the general microscope, there are more than 150 kinds of mycoplasma in nature. Clinical and basic research suggests that the impact of mycoplasma infection on fertility is not only objective, but also multifaceted. Mycoplasma urealyticum (Uu) is an important pathogen in non-gonorrheal urethritis (NGL). In men, Mycoplasma can travel up the genitourinary tract through the posterior urethra and prostate, invade the testicular seminiferous tubules, destroy spermatogenic cells, affect the meiotic process, interfere with spermatogenesis and maturation, leading to a significant reduction in sperm count and oligospermia; if a large number of Mycoplasma adsorbed in the sperm head, body and tail, fused with the surface of spermatozoa either directly or indirectly, it can cause spermatozoa to undergo convolutions, deformities, and swelling, making spermatozoa This can cause the sperm to become curled, deformed and swollen, resulting in abnormal morphology, increased deformity rate, and teratozoospermia. The toxic components and metabolites of mycoplasma may cause damage to the spermatozoa, resulting in decreased sperm vitality and viability, and weak spermatozoa. Infection of the prostate, seminal vesicle glands, epididymis, etc. can cause vasculitis, epididymitis, prostatitis, seminal vesiculitis, leading to changes in the physical and chemical properties of seminal plasma, destroying the environment in which spermatozoa live, so that spermatozoa mortality rate is increased, resulting in death, weak spermatosis. Mycoplasma infection caused by inflammation of the reproductive tract, in severe cases, can also cause obstruction of the vas deferens, oligospermia, azoospermia; inflammation can destroy the blood-testis barrier, producing anti-sperm antibodies, triggering immune infertility; due to the mycoplasma adsorption of spermatozoa, the production of neuraminidase-like substances, affecting sperm penetration into the egg cell, preventing sperm and egg recognition, fusion and a series of fertilization processes, leading to male infertility. Domestic and foreign data suggest that the culture positive rate of Mycoplasma hyopneumoniae in the cervical mucus and semen of infertile couples is as high as more than 50%, which shows that Mycoplasma hyopneumoniae infection may have a correlation with the occurrence of infertility. Another reason for the poor outcome of Mycoplasma solani infection is miscarriage, and some people have examined the positive rate of Mycoplasma solani from miscarried tissues as high as 40% or more. Therefore, the possibility of Mycoplasma lysimachiae infection should be considered in unexplained miscarriages, especially in those with multiple miscarriages. In the clinical diagnosis and treatment of male diseases, we attach great importance to the examination of the cause of the disease, such as urethral secretion, prostate fluid and semen mycoplasma and other pathogenic microorganisms of the ultra-high magnification microscopy, so as to achieve targeted treatment, targeted. Clinical diagnosis and treatment found that the combination of Chinese medicine and Western medicine for mycoplasma and other pathogenic microorganisms can more effectively improve the clinical treatment effect and increase the cure rate of the disease.