Mycoplasma infection problem at present in the results of the judgment of the existence of a great misunderstanding, many doctors are not clear about this problem, resulting in a large number of patients over-treatment, please read this article carefully: 1, hidden infection: MP-IgM positive or titer in 1:80 or more, and the patient does not have clinical symptoms, most often seen in adults or children during physical examination or suffering from other diseases. It is reported that about 14.9% to 16.0% of the healthy population are positive for MP-IgM, without fever and symptoms of infection, and do not need treatment. Infants infected with MP produce low IgM antibodies in the body, no clinical symptoms, with age, repeated mycoplasma infection-specific antibodies increase, symptoms can occur. 2.Infection for the first time, recent infection: can cause upper and lower respiratory tract infections, fever and respiratory symptoms, previously not checked MP-IgM, the titer at the onset of the disease can be up to 1:80, 1:160, 1:320 or more (the high one has up to 1:1,280), should be given to the treatment of macrolide drugs. 3.Previous infection: the history of MP infection 2-3 months ago, the MP-IgM titer is lower than the previous test results, no clinical symptoms, no treatment is needed. 4, re-infection (persistent infection, or recurrent infection): previous or recent (within 2 to 3 months) had suffered from MP infection, this test results titer higher than the previous test results, clinical symptoms again, clinical should be given macrolides treatment. 5.Mixed infection (dual infection): MP infection has been diagnosed or successively mixed with other pathogens ((combined bacterial or viral infection). Mixed infections are not rare in the clinic, and the possibility of mixed infections should be considered in children with severe MP infections and those who do not respond well to macrolide antibiotic therapy. Common community-acquired respiratory tract infections are the predominant mixed infection pathogens in children with MP infections, but occasionally mixed infections with two atypical organisms can occur.MP is primarily a mixed infection with pathogens such as respiratory syncytial virus, adenoviruses, pneumococcus, influenza virus, Chlamydia pneumoniae, and Haemophilus influenzae. Generally speaking, cases of mixed infections are younger in age, have a longer duration of illness, longer fever, and longer absorption of lung rhonchi and lung shadows. In recent years, it is found that MP infection is easy to cause EBV infection (infectious mononucleosis) or mixed infection of the two, it should be noted that the two are not only similar clinical symptoms, and both can cause a positive reaction of serum eosinophilic agglutination test, in this case, in addition to the administration of macrolides, should be given at the same time to give anti-inflammatory and antiviral treatment.