Our scholars conducted a total of 2,181 cases of Mycoplasma hyopneumoniae culture on infertile couples, and there were 1,203 cases of infection, accounting for 55.16%. Among them, 511 cases were male, accounting for 42.48%; 692 cases were female, accounting for 57.52%. It can be seen that the pathogen in China’s infertile couples in the infection of the prevalence. After mycoplasma infection through the urethra, patients may have urethritis symptoms, and may be secondary to chronic prostatitis. When examining the prostate fluid, a lively, swimming population of microorganisms can be seen. Mycoplasma also continues to infect the seminal tract, seminal vesicles and testes, affecting the quality of sperm and semen and causing infertility. It has been observed that mycoplasma can cause infertility through the following links. 1, interfere with sperm movement: sperm movement is an important function of healthy sperm, is an important indicator of whether the sperm can be fertilized, and sperm movement must have a certain speed and frequency. Mycoplasma infected sperm, often attached to the head and tail of the sperm, so that the entire sperm hung full of varying sizes of attachments, resulting in sperm swimming powerless, entangled with each other, resulting in infertility. 2, sperm deformity rate increase: mycoplasma infection leads to sperm deformity rate increase is caused by another feature of infertility. According to clinical observation, in this kind of infertility patients, sperm deformity rate can sometimes be as high as 80%. 3, the destruction of spermatogenic cells: testicular seminiferous tubules have a large number of spermatogenic cells, these spermatogenic cells through the development of reproduction to form spermatozoa. When mycoplasma enters the testicular seminiferous tubules from the urethra, prostate and other parts of the body, it will destroy the spermatogenic cells and produce shoddy products in the “spermatogenesis factory”, leading to infertility.