Duodenal bulb ulcers do not usually cause cancer. Duodenal bulb ulcers refer to peptic ulcers that occur in the bulb of the duodenum. Clinical manifestations vary, with most manifesting rhythmic and periodic epigastric pain, a few only having epigastric discomfort and dyspepsia, and some without any clinical symptoms. The chance of duodenal bulb ulcer to develop cancer is relatively small. The factors that cause stomach cancer mainly include long-term Helicobacter pylori infection, long-term stimulation of gastric acid or bile reflux, and other irritating foods. 1. Helicobacter pylori infection: if Helicobacter pylori is positive, not receiving regular treatment, and repeatedly stimulating duodenal ulcer for a long time. 2. Long-term stimulation of gastric acid or bile reflux: increased secretion of gastric acid and weakening of mucosal protective factors. Or cholelithiasis, cholecystitis caused by bile reflux for a long time. 3. Repeated long-term stimulation by irritating food: such as drinking a lot of alcohol, overeating, eating high salt and spicy food. It is recommended that the patient should go to the hospital in time and follow the doctor’s advice to take the correct treatment program.