Calf cramps that are still painful after a day may be caused by osteoporosis, lumbar disc herniation, thromboembolic vasculitis and other diseases, and patients can improve their condition through medication, physical therapy, surgery and other means. 1. Osteoporosis: patients can take calcium supplements, such as calcium carbonate, calcium citrate, vitamin D, drugs that inhibit bone resorption, such as salmon calcitonin, etc., and drugs that inhibit osteoclasts, such as zoledronic acid and alendronate, etc., and can also be treated with physical therapy through pulsed electromagnetic field, extracorporeal shock wave, microwave, and ultrashort wave, etc., in order to improve the symptoms. 2. Lumbar intervertebral disc herniation: non-steroidal anti-inflammatory drugs, such as meloxicam, etc.; muscle relaxants, such as epirubicin, etc.; dehydrating agents, such as mannitol, etc.; nutritive nerve drugs, such as methylcobalamin, etc., can be used for treatment, and physiotherapy can also be carried out through the use of medium and low-frequency electrosurgery and high-energy laser therapy, etc., and if the condition is serious, open surgery or minimally invasive surgery can be considered in order to improve the condition. 3. Thromboembolic vasculitis: patients should pay attention to keep warm and prevent the affected limbs from cold and moisture. Vasodilators, such as Conicardipine; thrombolytic and antifibrinolytic drugs, such as aspirin; antibiotics, such as ciprofloxacin; painkillers, such as indomethacin, can be used as prescribed by the doctor for treatment. Patients with severe disease can be improved by intravenous arterialization and endovascular treatment. It is recommended that patients strictly follow the doctor’s instructions, do not change the dosage of drugs or abuse drugs without authorization, and pay attention to monitoring the condition, if the condition worsens or other discomfort, it is necessary to consult a doctor in a timely manner.