Calf cramps may be related to cold irritation, muscle overwork, and arteriosclerosis occlusive disease of the lower limbs. Depending on the cause, general treatment, physiotherapy, medication, etc. can be used. There is no “fastest” treatment. 1. Cold stimulation: When the calf is stimulated by cold, it can lead to poor blood circulation in the calf, and the calf will cramp. It is recommended to keep warm, local hot compresses; usually more sunshine, eat more calcium-rich foods, such as milk, shrimp, soy products. 2. Excessive muscle fatigue: Excessive exertion can lead to muscle fatigue, muscle fatigue after a large number of acidic substances will be gathered in the calf, resulting in calf cramps. It is recommended to stretch the ankle joint immediately, and after the pain is relieved, local manipulation massage or hot compresses can be applied to promote blood circulation, so that muscle relaxation can relieve the symptoms of pain. 3. Lower extremity arteriosclerosis obliterans: this disease can lead to limb ischemia, hypoxia, resulting in calf cramps. It is recommended that the treatment of the primary disease, oral antiplatelet drugs, such as aspirin tablets, clopidogrel bisulfate tablets, but also oral antihypertensive drugs, such as cilostazol capsules, sagarate hydrochloride tablets and so on. Calf cramps can be relieved after the primary disease is cured. Calf cramps may also have other causes, it is recommended that the patient timely consultation, under the guidance of the doctor’s medication, do not blindly use drugs, so as not to delay the condition.