Elevated D-dimer can be seen in deep vein thrombosis, pulmonary embolism, DIC (disseminated intravascular hemolysis), after myocardial infarction, liver disease, malignant tumors, and hypercoagulable state of female pregnancy, etc. It is recommended to take anticoagulation and other treatments according to the cause of the disease. 1. In case of deep vein thrombosis of the lower limbs or pulmonary embolism, bed rest should be applied, avoiding massaging and squeezing the affected limbs; at the same time, anticoagulant drugs such as warfarin, rivaroxaban and subcutaneous injection of low molecular weight heparin should be applied under the guidance of doctors to inhibit thrombus formation and increase in size. 2. In case of DIC, we should first find out the cause of the disease and treat it, remove the triggering factors, closely monitor the patient, adopt symptomatic treatment measures such as oxygen absorption, correction of water-electrolyte disorders, etc., and apply heparin anticoagulant as appropriate, and fibrinolytic enzyme inhibitor treatment if necessary. 3. In case of hypercoagulable state in pregnancy, if there is no risk of thrombosis after evaluation, observation is sufficient, and anticoagulant treatment can be carried out if necessary. 4. If it is caused by malignant tumor, it is necessary to determine whether there is a risk of thrombosis after surgery, radiotherapy and other treatments for the original tumor before considering whether to carry out anticoagulation. In conclusion, it is recommended to find out the cause of elevated D-dimer and adjust the treatment strategy according to the cause of the disease. Timely consultation and treatment should be standardized.