Swollen hands bitten by unknown bugs can be applied locally with medication, oral medication, and enhanced care. 1. Topical application of drugs: If the symptoms are mild, not accompanied by pain and itching and other symptoms, you can use a weak glucocorticoid cream treatment, such as hydrocortisone acetate, methylprednisolone acetate and so on. If the symptoms are more obvious with burning sensation, pain, and severe itching, you can choose strong or medium-acting glucocorticoid ointment, such as Halcionide. 2. Oral medication: For the local application of drugs is not obvious, you can take oral antihistamines, such as fexofenadine, olopatadine and so on. 3. Enhanced care: accompanied by feelings of injury can use ice cold compress. Usually do not scratch with your hands, if there is a breakout, you should strengthen personal hygiene, do not contact with water as well as pollutants, keep the skin fresh and clean. Hands swollen by unknown bug bites, if there is no obvious recovery after simple treatment, to seek medical attention as soon as possible, do not delay the condition, if you need to use drugs, should strictly follow the doctor’s instructions.