Hepatitis B dna negative may progress to cirrhosis, it is recommended to check the liver function regularly, consult the doctor in time when there is any abnormality, and carry out treatment under the guidance of the doctor. Cirrhosis is a common chronic progressive liver disease in clinic, the pathology and histology show large area of hepatocyte necrosis, hepatocyte nodular regeneration, etc., the liver is gradually deformed, hardened and developed into cirrhosis. The most common cause of cirrhosis is hepatitis B, followed by alcoholic cirrhosis and schistosomal cirrhosis. Hepatitis B dna negativity indicates that there is no hepatitis B virus in the body or there is hepatitis B virus below the lower limit of detection, but it cannot be ruled out that unhealthy habits such as drinking alcohol will lead to cirrhosis, and the hepatitis B virus in the body may suddenly increase its replication ability, leading to the progression of the disease and then develop into cirrhosis. Hepatitis B dna negative may progress to cirrhosis and other diseases, it is recommended to check the liver function regularly and maintain a healthy lifestyle on the basis of usual treatment.