Ankle degeneration can be treated accordingly to the ankle symptoms, general treatment and medication are feasible in the early stage, and surgery may be needed in the later stage. Degeneration of the ankle joint mainly refers to the degeneration of the cartilage of the ankle joint, which in most cases is the manifestation of ankle osteoarthritis, such as ankle pain, impaired mobility, etc. The treatment is mainly to improve the symptoms and delay the degeneration. The treatment is mainly to improve the symptoms and slow down the degeneration. 1. General treatment: Ankle joint degeneration in the early stage will have pain and discomfort during joint activities, therefore, it is necessary to rest the ankle joint to avoid increasing the load on the ankle joint, which will lead to aggravation of the degeneration. 2. Drug therapy: Early ankle degeneration can be treated with non-steroidal anti-inflammatory drugs (NSAIDs) and nutritive articular cartilage drugs, which mainly reduce the aseptic inflammatory stimulation of the joint and slow down the degeneration of the cartilage. Non-steroidal anti-inflammatory drugs such as celecoxib, nutritive articular cartilage drugs such as glucosamine capsules. The medication should be taken under doctor’s supervision. 3. Surgery: In the late stage of ankle degeneration, if the above conservative treatment is ineffective, ankle arthroscopy or ankle fusion is needed according to the degree of degeneration. For specific treatment of ankle degeneration, please consult your doctor.