Creatinine 198μmol/L and high uric acid may be caused by chronic kidney disease, diabetic nephropathy, gout and so on, which can be treated by general treatment, medication and so on. 1. General treatment: health education should be provided to patients to avoid eating high purine food such as seafood and pig liver. Avoid taking drugs with high nephrotoxicity to prevent further deterioration of renal function. 2.Drug treatment (1) Kidney disease: For creatinine elevation caused by chronic kidney disease, mainly through the use of captopril, enalapril, candesartan and other drugs to lower blood pressure, reduce proteinuria, delay the deterioration of renal function creatinine. For creatinine elevation caused by diabetic nephropathy, in addition to the above treatments, it is also necessary to use hypoglycemic drugs such as metformin and insulin to strictly control the blood glucose level. (2) Gout: Uric acid level can be restored by using uric acid-lowering drugs such as allopurine and benzbromarone. When creatinine and uric acid are elevated, patients should seek medical advice as soon as possible, and improve relevant examinations such as liver and kidney function, abdominal ultrasound, etc. to assess the condition. Under the guidance of a professional doctor to use medication, avoid blindly use their own medication.