An elderly male, 65 years old, with a history of hypertension and atrial fibrillation. The patient had a sudden onset of slurred speech and right-sided limb weakness for 3 hours, and came to our emergency clinic, and quickly entered the “green emergency channel for stroke” of Nanjing Military General Hospital. The patient was given intravenous rt-PA thrombolytic therapy immediately after performing cranial CT examination and blood sampling, and there were no contraindications for thrombolysis. However, despite the thrombolytic treatment, the patient’s symptoms gradually worsened, and he became unconscious and irritable. The stroke team of our neurology department quickly started the interventional procedure, and performed cerebral angiography to show the occlusion of the left middle cerebral artery trunk. The patient’s condition stopped progressing on the same day, and the patient’s symptoms improved on the second day after the operation. After hospitalization, the patient recovered well and was discharged. This is a case of successful intravenous thrombolysis combined with mechanical embolization (bridge therapy – intravenous thrombolysis followed by mechanical embolization) in the treatment of severe cerebral infarction with large vessel occlusion. However, it is important to emphasize that patients should come to the hospital as soon as possible once they have a stroke. This is because both thrombolysis and mechanical thrombolysis require a window of time within a few hours of onset. And the earlier the treatment time, the greater the benefit.