Gallstones may change after more than ten years, for example, stones inside the gallbladder for a long time will lead to chronic inflammatory changes in the gallbladder, patients will have pain in the abdomen, sometimes the nature of the pain is mild, and sometimes the nature of the pain is also a bit more severe, it will be accompanied by indigestion, anorexia and other reactions. Acute inflammation of the gallbladder may be triggered if the patient has recently lost resistance, is tired or has eaten fatty foods. Patients may experience abdominal pain in the form of biliary colic, sometimes accompanied by nausea, vomiting and other obvious reactions. Stones in the gallbladder for a long time may gradually increase in size, or may form multiple stones, and the contractile function of the gallbladder may be affected. Gallbladder atrophy may occur, and gallbladder stones of the full type, which repeatedly irritate the gallbladder mucosa, may cause cancerous changes in the gallbladder.