Hormone-dependent dermatitis is a dermatitis caused by the long-term repeated and inappropriate use of hormonal topical drugs. Most commonly, the primary skin lesions disappear after long-term topical use of hormonal ointments, but inflammatory damage reappears after discontinuing use, requiring repeated use to control symptoms and gradually worsening. In recent years, the incidence of hormone-dependent dermatitis is on the rise, and it is stubborn and difficult to cure. The common hormonal topical medications are Paregoric Pine and Eloson, which have strong anti-inflammatory, anti-allergic and immunosuppressive effects and are commonly used to treat eczema and neurodermatitis. However, hormones are immunosuppressive drugs and can induce or aggravate infections, so they are not suitable for viral, bacterial and fungal skin diseases. For example, herpes simplex, acne, folliculitis, tinea pedis and other skin diseases should not be treated with hormone creams, as this may aggravate the condition and delay treatment. In addition, the elderly, infants and children, as well as patients with high blood pressure and diabetes, should also be careful with hormone ointments. Hormone ointments mainly target symptoms, and most of them treat the symptoms but not the root cause. Long-term self-application may cause skin atrophy, thinning, capillary dilation, folliculitis, skin flushing, drying, blackening or ichthyosis-like changes, or hair loss, hirsutism, hormonal acne, etc.