When it comes to hormone therapy, many people are afraid and will naturally think “there must be a lot of side effects”, which is caused by confusing other hormones with adrenocorticotropic hormone. In fact, there are many kinds of endocrine hormones, not only adrenal glucocorticoids, but also thyroxine, parathyroid hormone, sex hormones, growth hormone, melatonin, antidiuretic hormone, leptin, lipocalin and so on, and now even vitamin D can be categorized as a range of hormones. Various endocrine hormone functions and side effects are completely different, because the most used hormone in medicine is adrenocorticotropic hormone, such as: prednisone, dexamethasone, hydrocortisone, etc., it is indeed very big side effects, but there are more than 100 kinds of hormones in the human body, most of which are not like adrenocorticotropic hormone, as a lot of side effects. Such as hypothyroidism, long-term rational use of levothyroxine almost no side effects, diabetics use insulin all their lives, does not affect other endocrine functions, and do not use instead may be immediately fatal. Children need to be supplemented for zinc and calcium deficiency, as well as thyroxine deficiency, so why not growth hormone deficiency? Especially when supplementing the body for deficiencies, there is at least a health benefit. Of course, recombinant human growth hormone (rhGH) is, after all, foreign, and there are still some side effects. For example, occasional pain, numbness, redness and swelling at the injection site, etc. Generally, no treatment is needed and most of them can be relieved on their own. Individual patients will cause sodium retention, joint pain, etc., then as long as the dose of the drug is reduced or stopped for a period of time will be relieved or eliminated. Recently in the United States, there is also a case of growth hormone after the use of femoral head sliding off the report, but after all, very rare. In addition, the application of rhGH, due to the past growth of most of the slower, faster growth, the utilization of thyroxine may increase, a very small number of thyroxine failure to adjust the relative hypothyroidism (short-term supplementation is required) or over-adjustment (generally do not need to use medication), the growth hormone itself inhibits the role of glucose metabolism, occasionally see the phenomenon of high blood glucose, therefore, the need for regular monitoring of thyroxine and blood glucose. Since rhGH has certain side effects, is there any way to minimize its occurrence? First of all, the indications for the use of the drug should be strictly controlled, and it should be used only by those who need it. No medicine can be completely free of side effects. Those who do need to use it have to use it even if they have side effects, and those who don’t need to use it don’t have to use it even if they don’t have side effects. Secondly, before using rhGH, you need to do a detailed examination of pituitary MRI, liver and kidney function, blood sugar, hepatitis B two-to-half, etc. rhGH is not for everyone, and there are some contraindications, such as active tumors, diabetes mellitus combined with retinopathy. Because growth hormone will promote the growth of various tissues and organs, if there is a tumor in the body will also promote the growth of the tumor (but there is no tumor, does not induce the tumor; family history of tumors is not a contraindication to the use of rhGH in children, because the elderly in the family certainly did not use growth hormone, the tumors of the patients they have, certainly not caused by the injection of growth hormone). The safety of rhGH treatment will be improved by eliminating some factors that are not suitable for rhGH use. Thirdly, before using rhGH, it is necessary to do growth hormone stimulation test, check insulin-like growth factor, etc., to understand the level of growth hormone secretion of the person who needs to use rhGH, in order to correctly grasp the dosage of rhGH (too small a dosage may affect the effect, and the dosage is too large, which may increase the side effects), and the rational use of growth hormone, which can reduce the possibility of the occurrence of side effects. Fourth, in the process of medication, regular review of blood glucose, nail function, insulin-like growth factor, etc., to do a good job of monitoring the safety of medication, found that the problem, timely treatment, may reduce the occurrence of adverse consequences. Fifth, as this aspect of the treatment is a long-term process, and is completed in the family, the doctor should do a good job of training parents, parents also need to understand the relevant knowledge, there are problems can be recognized in a timely manner, timely treatment, may also reduce the likelihood of adverse consequences. Since human growth regulation is a complex process, the growth hormone stimulation test can only respond to the secretion of growth hormone, and cannot respond to whether the growth hormone activity secreted by the child is normal or not, nor can it respond to whether the amount of growth hormone receptor is normal or not, and how sensitive the receptor is? There are many links in the growth hormone axis, and many children who are not growth hormone deficient are also short, and have to use growth hormone to catch up with their height because there is no growth hormone receptor, etc. In July 2003, the U.S. Food and Drug Administration (FDA), the world’s toughest drug review organization, officially approved rhGH for use in non-growth hormone-deficient children. growth hormone deficient short children treatment for improving adult height. Since rhGH is approved for the treatment of non-growth hormone deficient children, safety and effectiveness are lacking. In the United States and Japan, rhGH for dwarfism is included in national health programs, and the European Society for Pediatric Endocrinology formally declared in 1993 that genetically recombinant human growth hormone (rhGH) for the treatment of dwarfism has good safety and efficacy. Since rhGH is a specially administered prescription drug and is a long-term medication, it cannot be used arbitrarily without a detailed examination. Before using rhGH, in addition to a detailed history and physical examination and a detailed assessment of bone age and prediction of adult height, growth hormone provocation test, thyroxine, liver and kidney function, blood test, blood glucose, MRI of the pituitary gland, and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP3) need to be checked. Some girls also need to check their chromosomes, and a very small number of boys may also need to check their chromosomes.IGF is an important indicator for judging the safety of rhGH treatment, and is also the main basis for dosage adjustment in the later stages of rhGH use. As this aspect of treatment is a long-term process, regular monitoring should be done, regular detailed assessment of bone age and growth and development, good evaluation of the efficacy of the treatment, timely adjustment of rhGH dosage, and the addition of other adjuvant therapeutic drugs if necessary. Different people have different sensitivity to drugs, if individualized and refined treatment can be achieved, it is not only conducive to improving the safety of rhGH treatment, but also more conducive to obtaining better therapeutic effects.