1. What is hormone-dependent dermatitis? A: Hormone-dependent dermatitis is called corticosteroid-dependent dermatitis or glucocorticoid-dependent dermatitis, also referred to as hormonal dermatitis, which is a non-purulent inflammation of the skin caused by the patient’s long-term repeated use of inappropriate or abusive topical corticosteroid preparations, causing the affected skin to become dependent on the drug, which can easily occur in patients with inappropriate use of topical glucocorticoid preparations for facial dermatology. Therefore, it is also often called facial hormone dependent dermatitis. 2.What kind of performance does hormone dependent dermatitis have? A: After using glucocorticosteroid topical preparations, the original disease improves rapidly, but cannot be cured; after treatment lasts for several weeks or months, once the drug is stopped, erythema, papules, tenderness, fissures, pustules, flaking, pain, itching, burning, tightness, and deterioration of the original disease occur within 1 to 2 days; when topical hormones are used again, the above symptoms quickly subside, and if the drug is stopped again, rebound dermatitis occurs rapidly, and is heavier than before. If discontinued, rebound dermatitis occurs rapidly and is more severe than before. To avoid the pain of rebound dermatitis after discontinuing the drug, patients rely entirely on topical hormones. The actual topical preparations are not effective and must be replaced with stronger hormonal topical preparations, or increase the dosage, or shorten the interval between medications, in order to improve the symptoms, the amount of medication is proportional to the length of the disease, the longer the disease, the more medication, the heavier the condition. 3.Why is the proportion of female patients with hormone dependent dermatitis much greater than the proportion of male patients? A: This is because women care more about their “face project” than men, and once they have discomfort on their face, they like to apply their own medicine in order to solve the problem quickly, and secondly, women prefer efficacious cosmetics to treat acne, pigmentation or sensitive skin, and many of these efficacious cosmetics have irregularly added hormone drugs. 4.What are the side effects of long-term topical use of hormones on the skin? A: When hormone creams are used on the face and pubic area for a long time, the side effects are relatively easy to occur because of the easy absorption of corticosteroids in these areas. dermatitis, etc. Especially for infants and young children, the skin is delicate and should not be used for a long time. If absorbed by the skin, it can also cause suppression of adrenal cortical function and bring serious adverse consequences. 5.Why do doctors use hormone creams when they have many side effects? A: Corticosteroids have anti-allergic effect of suppressing immune reaction, and can reduce congestion and edema after topical application, so that the degree of itching and inflammatory reaction of certain skin damage can be temporarily relieved and subside. 6.What are the common hormone creams on the market? A: Due to the publicity effect of manufacturers’ advertisements, the names of many hormone creams are not unfamiliar among the general public, such as dermatologic cream, dermatoplanin cream, skin relief cream, compound Connor cream, skin cream, skin lotion, etc. Among them, dermatologic cream contains the most potent preparation of clobetasol, which also causes the highest proportion of side effects, these drugs are commonly used in dermatology and have different curative effects on various skin diseases, but patients should not The dermatologist should strictly use the medication under the guidance of the dermatologist. 7.What kind of skin atrophy or erythema (capillary dilation) is likely to occur under the circumstances of hormone topical application? A: If the medication is applied for too long or the area used is too large. 8.Why do some blemish creams or desensitizing cosmetics cause hormone dependent dermatitis? A: This is because short-term use of hormones has a whitening effect or anti-allergic effect on the skin, but long-term repeated use will cause skin and systemic damage and make the skin produce hormonal dermatitis. In the Ministry of Health cosmetic adverse reaction monitoring work found a number of beauty salons in the use of cosmetics to do skin beauty or the so-called desensitization treatment of consumers, after the discontinuation of cosmetics skin erythema, papules, exudation, capillary dilation and pigmentation and other clinical manifestations of hormone-dependent dermatitis. Some of the cosmetics were found to have hormone-like substances added illegally. 9.Why does hormone-dependent dermatitis occur? A: The exact pathogenesis is not yet fully understood, but may be related to skin atrophy caused by corticosteroids. Skin atrophy leads to thinning of the stratum corneum, degeneration of dermal papillae, and loss of the skin barrier against water loss, which rapidly causes dryness and inflammation. Skin dehydration may be the main cause of inflammation in normal or existing lesions. 10.How to reduce and stop hormones in the treatment of hormone dependent dermatitis? A: The question of how to treat hormone discontinuation in the treatment of hormonal dermatitis is a matter of benevolence and wisdom, which is generally summarized in the following three ways: First, the strong hormone used by the patient is replaced by a weak hormone until it is discontinued, during which other non-hormonal drugs are used to assist in the treatment, so that the skin has a gradual adaptation to the transition process; second, the concentration of the hormone cream used is gradually reduced, and the interval is extended. Third, the topical use of hormonal creams should be completely stopped and replaced by non-hormonal creams. As for how to reduce and stop hormones for each specific patient, it depends on each person’s different condition and the dermatologist’s medication experience. It is the right choice for patients to follow the dermatologist’s medical advice to treat hormonal dermatitis in a regular hospital. 11.What are the best topical drugs for treating hormone dependent dermatitis? A: Tacrolimus ointment and pimecrolimus cream are local immunomodulators, which are used to treat hormonal dermatitis with good effect both at home and abroad, and others include heparin sodium ointment, xiheptal cream, zinc boron cream, zinc oxide cream, and furnace glycolic lotion. When the skin is dry and astringent in the later stage of recovery, non-stimulating moisturizing skin care products can be added appropriately, such as Avène, Richland and other medicinal products or Shanghai Bacitracin brand Vaseline moisturizing cream, etc. 12.Is there any internal medicine for treating hormone dependent dermatitis? A: For stubborn hormonal dermatitis or severe hormonal dermatitis, patients can take oral antihistamines, immune regulating drugs, Chinese herbal medicine and other drugs under the guidance of doctors. 13.What should I do for hormone-induced red blood cells (dilated capillaries)? A: Photorejuvenation and laser cosmetic instruments can be applied to treat it. 14.What are the contraindications and precautions for hormone dependent dermatitis? A: During the treatment period, it is advisable to eat light food and avoid some spicy and stimulating food and alcohol. Due to the long treatment period of this disease, patients should maintain a good state of mind, do not get angry and anxious. 15.How long does it take to cure hormone dependent dermatitis? A: Hormonal dermatitis generally takes from 2 months to 2 years, and the cure time is proportional to the strength and time of the hormone preparations used topically; moreover, after the facial lesions disappear completely, there is still a high degree of skin sensitivity, so it takes longer to recover completely; at the same time, secondary hyperpigmentation and erythema (dilated capillaries) are also problems that exist after patients are cured. 16.How to prevent the occurrence of hormone dependent dermatitis? A: Patients with skin diseases, especially facial skin diseases, must use medication under the guidance of dermatologists in regular hospitals, and should not purchase medication on their own or find non-dermatologists to prescribe hormone creams for a long time. Secondly, avoid self-use or use of efficacious cosmetics in beauty salons to avoid the harm of hormones that may be contained in them to unknowingly use the skin.