Hormones are used in a variety of ways, including systemic medications such as oral, intramuscular, intravenous, or intravenous drips, as well as inhalation, topical injections, and applications. Topical glucocorticosteroids are primarily used to treat proliferative, inflammatory, and immune-related skin conditions, as well as to relieve itching and burning, and are generally not used for infectious diseases. Diseases that glucocorticoids do treat effectively include psoriasis, vitiligo, atopic dermatitis, eczema, acute radiation dermatitis, and lichen planus; they may be effective for melasma, chronic idiopathic urticaria, and pemphigus vulgaris. Weakly potent hormones can be used on the face, inguinal, axillary, genital, and perianal areas; strong or super-potent glucocorticoids are commonly used for palmoplantar, moss-like, and hypertrophic lesions; super-potent agents should be used in a short course of therapy (2-3 weeks), or with intermittent therapy. Sequestration is commonly used for palmoplantar lesions to facilitate drug penetration into the thicker stratum corneum. The most common adverse effect of topical glucocorticosteroids is skin atrophy, which occurs with all topical glucocorticosteroids, with an increased risk with higher-strength glucocorticosteroids, sealing therapy, thinner skin, and older patients. The face, dorsum of the hands and interpunctal areas are more sensitive and may disappear after discontinuation of use lasting several months. Hormones are not a panacea and are contraindicated in infectious dermatoses; the possibility of an infectious dermatosis should be considered in any rash that worsens or does not improve significantly with topical glucocorticosteroids. Confirmation of the diagnosis before use. Topical use of hormones may also cause contact dermatitis, photosensitivity. Hyperpigmentation, hypopigmentation, hirsutism, perioral dermatitis, acne, hormone-dependent dermatitis, delayed wound healing. AND SYSTEMIC ADVERSE REACTIONS: Topical application of potent and ultra-potent glucocorticoids can be absorbed into the body causing systemic adverse reactions, inhibition of the hypothalamic-pituitary-adrenal axis, glaucoma, aseptic necrosis of the femoral head, hyperglycemia, and hypertension. Topical glucocorticoids are usually recommended to be used once or twice daily. Excessive use does not produce better efficacy, and prolonged use of topical glucocorticosteroids can produce tolerance and rapid resistance. Ultra-potent glucocorticosteroids should not be used continuously for more than 3 weeks, and if the course of treatment is prolonged, it should be tapered and then discontinued to prevent rebound symptoms. If glucocorticosteroids are to be continued for at least 1 week after discontinuation, this intermittent treatment program can be repeated until symptoms are completely resolved. In children, underdosage (compromising efficacy) or overdosage (producing local or systemic adverse effects) should be particularly avoided.