The hormone we usually refer to is glucocorticoid, which is a general term for several steroid substances secreted by the adrenal glands. Prednisone, cortisone, hydrocortisone, dexamethasone, etc. in doctors’ prescriptions are They are synthetic substances. These hormones are essential for maintaining life, raising blood sugar, promoting protein and fat decomposition to provide heat, enhancing heart function, promoting appetite, reducing fever, and suppressing the body’s immune process. It is often used in the treatment of asthma, nephrotic syndrome and many autoimmune diseases, as well as in the resuscitation of critically ill patients, and is necessary for people with hypoadrenocorticism. Like other drugs, hormones have therapeutic effects but also have many adverse effects, such as causing hyperadrenocorticism, inducing infections and ulcers at home, osteoporosis and spontaneous fractures, aseptic osteonecrosis, effects on reproductive function and children’s growth and development, and behavioral and psychiatric abnormalities. It is especially important to apply hormones appropriately and to strictly control the indications and contraindications. Hormone therapy is mainly used for severe infections complicated by toxemia, acute and chronic hypoadrenocorticism, hypopituitarism and replacement therapy after subtotal adrenalectomy, autoimmune diseases, allergic diseases, shock caused by various reasons, and prevention of sequelae of certain inflammatory diseases. Use with caution for viral infections. Contraindicated in patients with hyperadrenocorticism, hypertension, gastric and duodenal ulcers, heart failure, psychosis, obese diabetes mellitus, chronic malnutrition, etc. Other adjuvant drugs should be applied promptly. Long-term use of hormones should be given promptly to promote corticosteroids to prevent hyperalgesia; at the same time, potassium and calcium supplementation to prevent low blood potassium and calcium deficiency causing convulsions, and disease to limit sodium intake. Patients should understand the course of medication hormone in the early application of a large number of full application. There are immune cells T lymphocytes and B lymphocytes in the human body, which are both manufactured by red bone marrow cells said in the bone marrow, B lymphocytes are involved in humoral immunity and T lymphocytes are involved in cellular immunity. They both produce immune responses. The development of kidney disease is mainly triggered by the immune response, and hormones are applied to suppress the immune effect of lymphocytes. And it is because the effect of hormone on immune cells is inhibition rather than killing, so only sufficient amount of long-term use of hormone can play a role in suppressing immune response and achieve the desired effect. The usual dose is 0.5 mg/kg, maintained for 1-2 months and then reduced. When a patient needs to use hormones, it is important to be clear about how long the course of hormone therapy is planned to be. If the disease requires only a very short course of hormone, such as 1-3 days, use it for no more than 5 days at most; if the disease is an incidental allergic disease (severe and life-threatening laryngeal edema), a drug with stronger anti-inflammatory and anti-allergic effects and method of administration should be used. If oral prednisone or intravenous dexamethasone is administered three times daily, not much consideration needs to be given to the long-term adverse effects of the hormone. However, in most cases, clinical use of hormones requires a long course of treatment, such as systemic lupus erythematosus, nephrotic syndrome, and idiopathic thrombocytopenic purpura. The dosage should be slowly reduced when discontinuation is needed If discontinuation is needed, hormones should not be discontinued arbitrarily, there should be a gradual reduction process, and sudden discontinuation will cause rebound of the disease. There are two concepts to understand when using hormones. Hormone resistance: Hormone resistance can be considered as hormone resistance if the hormone is ineffective after 8 weeks of full dose use. Ineffectiveness is defined as more than 3 times of disease relapse within one year of standardized hormone use; Hormone dependence: the phenomenon of disease rebound under the condition of standardized drug discontinuation. If proteinuria occurs again, it can be regarded as hormone dependence. The application of adrenocorticotropic hormone is very complicated, and ancient patients should never take the initiative to reduce or stop the medication, and must follow the medical advice to recover as soon as possible.