Glucocorticoids are effective in the treatment of kidney disease in most cases, but if the hormones are ineffective, the following factors should be excluded 1. The presence of complications of glucocorticoid efficacy, such as infections, in addition to manifest infections, such as lung and urinary tract, and sometimes very latent infections, such as gum infections and toe infections. 2, nephrotic syndrome presents severe edema, resulting in The digestive function of the gastrointestinal tract is significantly reduced, and oral hormones often do not have the desired effect. 3, the influence of liver function, prednisone needs the conversion of the liver into prednisolone in order to play the pharmacological effect, so abnormal liver function has an impact on the metabolism of hormones. When liver function is abnormal, appropriate hormone therapy should be used. 4.Drug interactions, such as carbamazepine, kauleenamine, rifampin, etc. can reduce the blood concentration of hormone. 5.Some types of kidney disease, such as focal segmental glomerulosclerosis, membranous nephropathy, membrane proliferative nephritis, etc., respond poorly to hormones. 6, renal vein thrombosis, nephrotic syndrome of the hypercoagulable state, easy to form venous thrombosis, especially membrane nephropathy about 50% will appear renal vein thrombosis. Hormones promote blood hypercoagulation, and patients with renal vein thrombosis have poor hormone efficacy.