Gallstones of 1.5 cm are not particularly large and not particularly serious. However, the overall severity of gallstones needs to be evaluated by a combination of factors, and a single judgment of the size of the stone is not always accurate. The need for surgical treatment is also based on a comprehensive assessment of factors.1. Symptoms: If the patient has a stone of 1.5 cm, it depends on the severity of the symptoms, whether the symptoms are recurrent, whether there is a combination of acute pancreatitis, biliary obstruction, jaundice and a series of other manifestations, and whether the symptoms can be controlled with active conservative treatment. If the effect of conservative treatment is not satisfactory, patients with recurrent attacks should consider surgery even if the stone is only 1.5cm; 2. Combined diseases: If gallstones 1.5cm are combined with severe cholecystitis and significant thickening of the gallbladder wall, early surgery should be considered in this case. In addition, if there is a combination of gallbladder atrophy, abnormal gallbladder function, local gallbladder thickening, or gallbladder polyps more than 1cm, all belong to more serious cases and need to consider surgical treatment. At this time, surgery is mainly to prevent the risk of other complications or even cancer later; 3. Number of stones: If the simple gallstones 1.5cm, it is relatively not particularly serious. However, if the stones are multiple, about 1.5cm in size, occupying more than 2/3 of the entire gallbladder space, it is a more serious case and requires surgery; 4. Patient’s general condition: whether the patient has had other related surgeries, whether he/she has had high-risk surgeries, whether he/she has other high-risk inflammatory gallstone attack factors, all these should be evaluated comprehensively. Overall, gallstones of 1.5 cm are not considered particularly serious, and the need for surgery should be integrated with these factors for an overall assessment.