Hepatitis B virus core antibody and surface antigen are positive, and the condition is relatively serious if the patient has impaired liver function or abnormal liver morphology. Hepatitis B surface antigen and hepatitis B core antibody are positive in hepatitis B five items, mostly suggesting acute HBV infection, chronic HBsAg carriers, and less infectious. For acute HBV infection, you need to go to the regular hospital in time for scientific and reasonable treatment to avoid delaying the condition. For chronic HBsAg carriers need to be analyzed in conjunction with liver function, ultrasound, family history, etc. If there is no damage to the liver and no risk factors, medication may not be necessary, and regular review is sufficient. If the liver function is damaged and liver ultrasound is abnormal after testing, timely antiviral treatment is needed. Patients with abnormal hepatitis B five, need to go to the hospital, the relevant examination to further clarify the condition, they can not randomly use drugs.