Two-positive, one-negative breast cancer does not necessarily recur 100% of the time. Two-positive, one-negative breast cancer is generally defined as ER-positive, PR-positive, and HER-2-negative breast cancer. Double-positive hormone receptor breast cancer is usually characterized as Luminal breast cancer, which is relatively less invasive due to the low reproduction index of cancer cells. Luminal breast cancer usually has a better prognosis and a lower chance of recurrence, so patients do not need to be overly worried, and should set the right mindset and take positive treatments. Luminal breast cancer should follow the principle of early detection and early treatment, and once detected, the diseased area should be completely removed through surgery. Patients also need endocrine therapy after surgery, and can use drugs such as anastrozole or toremifene under the guidance of doctors. If the patient is unable to undergo surgery, doxorubicin, paclitaxel and other drugs can be used for chemotherapy. Breast cancer patients should actively consult and review in regular hospitals, and standardize the treatment under the guidance of doctors.