Highly differentiated adenocarcinoma of colon infiltrating into the plasma layer represents advanced stage of colon cancer, which can be treated with surgery, radiotherapy and targeted therapy according to whether it is metastatic or not. 1. Invasion to the plasma layer without metastasis: if colon adenocarcinoma invades to the plasma layer without metastasis, surgery can be performed to remove the colon and the whole area lymph nodes. If colon cancer patients cannot tolerate surgical treatment, they can undergo chemotherapy first, and strive for the transformation of the disease to a resectable state before resection. 2. Metastasized: colon cancer tumor cells have metastasized to liver or lungs, if the metastasis is small, surgical resection can be performed and supplemented with chemotherapy. When the metastasis is to the peritoneum, most of them choose palliative radiotherapy treatment. Those with obvious mutation gene positivity may choose targeted therapy. Specific treatment needs to be decided according to the severity of the disease, patients and their families should follow the doctor’s treatment plan and actively treat, do not lose confidence, give up treatment, and delay the disease.