A normal cerebrospinal fluid test can rule out neurosyphilis. Neurosyphilis must be diagnosed by a cerebrospinal fluid test, and a negative cerebrospinal fluid test indicates the absence of neurosyphilis. Neurosyphilis is an infection of the central nervous system with syphilis spirochetes. Congenital infection is transmitted from a pregnant woman to her fetus through the placenta, and acquired infection is mainly through high-risk sexual behavior or blood transmission. Neurosyphilis mainly invades the central nervous system of the body and may take years or decades to cause symptoms of neurological damage. Most people do not have any symptoms for about 1 to 2 years after infection, and the diagnosis of neurosyphilis is confirmed only when abnormalities are detected in the cerebrospinal fluid. Neurosyphilis can mainly invade the meninges, causing inflammation of the meninges leading to headache, nausea, vomiting, stiff neck, etc. In severe cases, it can lead to visual or auditory abnormalities, mania, epilepsy, etc., and ultimately lead to the patient’s inability to take care of himself. The treatment of neurosyphilis is mainly penicillin, ceftriaxone, with painkillers and seizure medication if there are symptoms of meningeal irritation. The prognosis of neurosyphilis is poor, generally the chance of complete return to normal is relatively small, and most of them will affect life expectancy if timely treatment is not carried out. If cerebrospinal fluid abnormalities occur in neurosyphilis, you need to actively go to the hospital for treatment, and the use of drugs under the guidance of a doctor.