Hepatitis B core antibody positive and other negative indicates that the patient has been infected with hepatitis B virus in the past, and has been self-healed or cured, occult hepatitis B, acute hepatitis B window period. 1. Infected with hepatitis B virus, already cured or cured: as some patients will rarely develop disease after exposure to hepatitis B virus, most of them have hidden infection, and after self-cure, they may be positive for hepatitis B core and surface antibodies, and if hepatitis B core antibody positivity exists for a long time, hepatitis B core antibody positivity and other negativity will occur. 2. Occult hepatitis B: patients can detect horizontal replication of hepatitis B virus in serum, and can detect hepatitis B core antibody positive other negative. 3. Acute Hepatitis B window period: Hepatitis B surface antigen exists for a short period of time, and the test may not be able to detect it. While hepatitis B core antibody positivity exists for a long time, hepatitis B core antibody positivity and other negativity will occur. When the patient’s hepatitis B core antibody is positive and other is negative, it is recommended to go to the hospital in time, improve further examination if necessary, and follow the doctor’s instructions for regular review.