What exactly is obese? You should be re-aware of this! Why do people become obese? The most classic explanation is too much energy intake, too little consumption. In layman’s terms, it means “eat too much, move too little”. For people who have experienced weight loss, more or less experienced to control the diet, strengthen the exercise method to slim down, commonly known as “control mouth, open legs”. This is also based on the law of conservation of energy, to keep the intake lower than the consumption and weight loss. Is there any other possibility: in addition to the law of conservation of energy in physics, obesity is also influenced by other factors? A, the obesity gene is haunted in recent years, scientists are happy to “obesity gene” research. We also found many obese patients in the clinic have a family history of obesity, scientists are increasingly sure that many obesity is caused by genetic genes. In July 2013, the American Journal of Clinical Investigation published a report saying that the “obesity gene” called fto can increase the level of “hunger hormone” in the body, and make people more interested in high-calorie food, and thus easy to gain weight. Ghrelin, a 28-amino acid gastrointestinal peptide hormone, was first discovered to be secreted by gastric mucosal P/D1 cells and pancreatic epsilon cells. Further studies revealed that it can also be produced and secreted in the small intestine, colon, lungs, gonads, adrenal cortex, placenta, kidneys and brain. One important reason why stomach reduction surgery can be successful in weight loss is that it alters the levels of hormones in the gastrointestinal tract, allowing obese people to feel less hungry and reduce their appetite. More than 200 genes or chromosomal regions associated with obesity have been identified to date. What is more terrible is that many of these obesity genes are in the fetal period to start the role, and the external environment will also accelerate this role. Second, hormone regulation disorder Talk about the most important insulin (Insulin), insulin is a hormone secreted by specific cells in the pancreas, is the only hormone that can reduce blood sugar in the body, it can also promote the synthesis of glycogen, fat and protein. Under normal circumstances, when the glucose concentration in the blood rises after we eat, the pancreas releases more insulin to keep the concentration of glucose in the blood at a safe level. It provides energy to cells such as muscles and liver, while converting excess glucose to glycogen or converting it to fat for storage as back-up calories. The higher the glycemic index we consume refined, highly pasted foods, the greater the rise in glucose concentration in the blood and the greater the release of insulin. (bmr) is the rate of energy metabolism when the body is awake and extremely quiet, not affected by muscle activity, ambient temperature, food and mental stress), making it impossible to convert energy in a timely manner, and more and more fat is stored leading to obesity. The relationship between insulin resistance and the development of metabolic syndrome will be discussed in detail in a later article. Therefore, some scholars believe that obesity, like other physiological disorders, is related to defective hormone regulation. In recent years, many scholars proposed “appropriate control of carbohydrate intake, especially the intake of refined sugar and refined processed foods” can help weight loss. Third, the intestinal microbial imbalance intestinal flora is the presence of a large number of microbial groups in the intestine of animals or humans, to help the host to complete a variety of physiological and biochemical functions, there are many scientists have put the focus of disease research on these inconspicuous, “smelly” intestinal flora, including endocrine diseases, neuropsychiatric diseases and so on. In 2006, the U.S. Genome, based on macrosequencing of human gut microbes, analyzed the gene functions of gut microbes and showed that the gut microbial genome is rich in genes involved in the metabolism of carbohydrates, amino acids, methane, vitamins and short-chain fatty acids, a large proportion of which have metabolic functions that the human body does not possess, indicating that gut microbes are important players in human metabolism. It was found that obese individuals had a lower proportion of Bacteroides phylum and a higher proportion of Actinobacteria phylum in the gut compared to lean volunteers. Seventy-five percent of the gut microbial genes in the obese volunteers were derived from Actinobacteria, while 42% of the gut microbial genes in the lean volunteers were derived from the phylum Actinobacter. It has also been shown that the proportion of thick-walled phylum is higher in the gut of obese individuals compared to normal individuals, and when weight loss occurs the proportion of thick-walled phylum in the gut becomes more similar to normal individuals. Perhaps in the future, we can change the microorganisms in the gut to control weight and open up a new way for foodies to eat without gaining weight. Of course, the reasons for obesity is not only these factors, with the development of medicine we will slowly unravel its mystery.