SAPHO syndrome is not a cancer, it is a rheumatic immune disease and a seronegative spondyloarthropathy, which usually presents as a bone and joint injury with characteristic skin lesions. The disease is highly heterogeneous and varies widely in presentation, and may present with acne, purulent sweat glands, or palmoplantar pustulosis, as well as with joint involvement, mostly in the anterior chest wall or in single or multiple peripheral joints. Pain and swelling of the anterior chest wall is the main cause, usually bilateral, and is aggravated by damp and cold weather. Bone hypertrophy may also compress adjacent neurovascular structures, sometimes requiring surgical intervention. Bone lesions may also occur in the spine, long bones, iliac bone, mandible, and pubic bone.