Chloasma on the face of a woman in her forties can be treated with medication, physical therapy, and general measures to regulate the condition. Chloasma is most common in young and middle-aged women, and men can also suffer from it. The lesions are often symmetrically distributed on the cheeks and cheeks of the face and are butterfly-shaped. Chloasma can be caused by various reasons, such as ultraviolet radiation, cosmetics, pregnancy, endocrine disorders, race and heredity. It can be treated in the following ways. 1. Medication: Apply 2% hydroquinone cream and other depigmenting agents on the affected area under doctor’s instruction. In addition, vitamin C and tranexamic acid can be taken orally, and in severe cases, vitamin C can be injected intravenously. 2. Physical therapy: laser or Q-switched large spot low-energy laser chloasma has certain therapeutic effect. 3. General measures: usually ensure enough sleep, keep a good mood and avoid anxiety and tension. Patients should pay attention to sun protection when going out, apply sunscreen and wear an umbrella and a hat. It is recommended to consult doctor in time and choose appropriate measures for treatment under doctor’s guidance for chloasma on the face of over forty women.