Termination of pregnancy is usually recommended for fetuses diagnosed with hypoplasia of the corpus callosum because the disorder is incurable and very harmful. 1. Abnormal appearance: It may lead to abnormal appearance such as oversized or undersized head circumference, small chin, cleft lip and palate, and strabismus. 2. Visual impairment: It may lead to abnormal appearance such as wide eye spacing or strabismus, which has a great impact on vision and may even cause cataracts or strabismus. 3. Nodding spasticity: it may lead to adverse effects on neurodevelopment, resulting in epileptic symptoms such as uncoordinated neurological and motor movements, causing nodding spasticity, resulting in persistent unconscious nodding of the child’s head. 4. Mental retardation: if the condition is not too serious, it may lead to mild mental retardation; if the condition is more serious, it may even cause intellectual disability. Therefore, Corpus Callosum Hypoplasia is very harmful and pregnant women are recommended to receive treatment for termination of pregnancy under the guidance of specialists.