How to treat hypofractionated adenocarcinoma of the lung? First of all, it depends on the stage. If early and intermediate stage lung cancer, stage 1, 2, 3a patients can have the chance of surgery, try to have surgery as early as possible, and after surgery, according to the patient’s pathological status, decide whether to have adjuvant chemotherapy, adjuvant radiotherapy, and adjuvant targeted therapy. If there are some specific types of mutations, such as EGFR and ALK mutations, the next step is targeted therapy. If there are no genetic mutations, PD-L1 expression is tested and if PD-L1 is strongly positive a separate immunotherapy is performed. If weakly positive or no expression, immunotherapy combined with systemic chemotherapy, and radiotherapy is administered.