Vomiting in mycoplasma infection is mostly considered to be gastric discomfort caused by taking medication for mycoplasma, which can be relieved after suspending the medication, or adjusting the medication with antiemetic drugs. Prolonged vomiting has the possibility of gastric disease, this time should improve the examination, for the cause of the treatment. Mycoplasma often infects the lungs, genitourinary tract, generally not infect the digestive system, the treatment of mycoplasma infections commonly used macrolide antibiotics, such as azithromycin, as well as quinolone antibiotics, such as levofloxacin, moxifloxacin, and so on, these drugs often lead to dyspepsia, diarrhea, nausea, vomiting, headache and so on, and thus may cause the patient to vomit. Patients with chronic recurrent vomiting should undergo gastroscopy and other tests to rule out the presence of gastric disorders, and if there is gastritis, gastric ulcer, etc., they will be treated as gastric disorders. If there is any discomfort, it is necessary to consult a doctor in a timely manner to clarify the cause and then standardize the treatment, so as to avoid delaying the condition.