Background: Proteinenergymalnutrition (PEM) is prevalent in patients on maintenance hemodialysis (MHD), and serum albumin, an indicator of malnutrition, is significantly associated with morbidity and mortality in hemodialysis patients. Overall patient serum albumin has not improved over the past 10 years, so there is a need to re-evaluate traditional nutritional interventions. Intradialyticparenteralnutrition (IDPN) is a convenient parenteral nutrition intervention given during hemodialysis for patients whose nutritional status is not improved by conventional oral or enteral nutrition. In this paper, we want to demonstrate that partial parenteral nutrition in dialysis can safely and effectively improve the nutritional status of patients. OBJECTIVE: To evaluate the effectiveness and safety of simple parenteral nutrition on dialysis as a nutritional intervention for malnourished hemodialysis patients. METHODS: This trial was a prospective, randomized, controlled trial in which 36 patients were randomly divided into three groups: 1, control group. 2, 50% glucose intervention group. (3, 8.5% amino acid intervention group). Nutritional status indicators and other biochemical indicators were measured before and after the trial. The nutritional indicators of the glucose and amino acid intervention groups were higher before and after the intervention, especially PA, TRF and PCR, with significant differences (P < 0.05); however, one-way ANOVA between the glucose and amino acid intervention groups and the control group showed no statistically significant differences (P > 0.05). 2. The levels of glutamate, tryptophan and leucine were significantly increased in the 50% glucose intervention group with a significant difference (P < 0.05), and the levels of glutamine, threonine, tyrosine, valine, phenylalanine, leucine, essential amino acids and total amino acids were significantly increased in the 8.5% amino acid intervention group with a significant difference (P < 0.05). When comparing with the control group, it was observed that all free amino acids in serum except arginine tended to increase in the 50% glucose intervention group and the 8.5% amino acid intervention group, but it was not significant (P > 0.05). When compared with the control group, it was seen that essential amino acids and total amino acids were significantly higher in the 50% glucose intervention group and the 8.5% amino acid intervention group (P < 0.05), and there was no significant difference between these two groups (P > 0.05). 3. There was no significant difference in triglycerides, cholesterol, low-density lipoprotein and C-reactive protein before and after the intervention in the three groups (P > 0.05). There was no significant difference in serum calcium, serum potassium, and calcium-phosphorus product before and after intervention in the three groups of patients (P > 0.05). There was no significant difference in plasma CO2 levels before and after the intervention in the three groups (P > 0.05). Conclusions: 1, Both 50% glucose and 8.5% amino acids titrated during dialysis improved the nutritional indicators and the free amino acid profile in the serum of the patients, while the use of amino acids was more effective in improving the amino acid profile in the blood. 2, There were no serious side effects of both methods in the study. 3, Serum prealbumin and transferrin can be used as earlier and sensitive indicators to respond to nutritional status.