Leukemia nosebleeds can be unilateral or bilateral. Clinically, patients mostly show symptoms of diffuse bilateral nasal mucosal bleeding, but it is not possible to suspect whether they have leukemia just by virtue of the one symptom of nosebleeds. Patients with leukemia may experience bleeding from various parts of the body due to inhibition of the normal bone marrow hematopoietic function and impaired coagulation. This includes nosebleeds, which are caused by rupture of blood vessels in the nose and adjacent tissues, either unilaterally or bilaterally. There is also usually bruising, bruising of the skin, bleeding gums, etc., and the bleeding is not easily stopped. Clinical diagnosis of leukemia requires a comprehensive evaluation of the patient’s clinical presentation, hematological findings, and bone marrow picture characteristics to make a definitive diagnosis. There are many causes of nosebleeds. The most common causes such as nose-digging, impact or dry nasal mucosa can cause bleeding, and disease factors such as rhinitis, sinusitis, and deviated nasal septum can also cause bleeding. Usually, the symptoms can be relieved by applying pressure to stop the bleeding. In addition, patients suffering from nasal polyps, hemangiomas and other diseases with abnormal nasal redundancy, as well as patients suffering from bleeding disorders (such as aplastic anemia, hemorrhagic fever, leukemia, etc.) can also develop nasal bleeding, which often recurs and is not easy to stop. Therefore, if nosebleeds occur, do not worry too much and just stop the bleeding in time. However, if nosebleeds occur repeatedly, it is recommended to seek medical attention in a timely manner to clarify the diagnosis so as not to delay the condition.